Pineapple Express is a sativa hybrid cross of Hawaiian and Trainwreck which became a household name after James Franco and Seth Rogan’s popular film by the same name. Pineapple Express has a tropical, pineapple, fruit, and pine profile and it is best suited for daytime use. Pineapple Express will have you feeling creative, energetic, euphoric, and focused and is used to help treat depression, stress, and chronic pain.